Ingredient Highlight

Hypochlorous Acid

It’s a natural molecule that your white blood cells produce to kill harmful microbes and calm inflammation. In skincare, it’s replicated in a super diluted form to make it safe and soothing for daily use. 

November 26, 2025
5 min read
Hypochlorous Acid

Hypochlorous Acid: The Gentle Germ-Fighter Your Skin Secretly Loves

Hypochlorous Acid might sound intense — almost like something you’d find in a chemistry lab, not your skincare routine. But don’t let the name fool you. This ingredient is actually one of the most skin-friendly, effective, and underrated multitaskers out there. In fact, your body already makes it — it’s part of how your immune system fights off bacteria and heals wounds.

Wait, What Is Hypochlorous Acid?
It’s a natural molecule that your white blood cells produce to kill harmful microbes and calm inflammation. In skincare, it’s replicated in a super diluted form to make it safe and soothing for daily use. Despite how scientific it sounds, it’s incredibly gentle — even safe for use around the eyes, mouth, and broken skin. That’s rare.

What Does It Actually Do?
Hypochlorous Acid (often shortened to HOCl) is like a cleanup crew for your skin. It helps kill bacteria, reduce redness, and calm irritation — all without disrupting your skin barrier or causing dryness. It’s especially helpful if you’re dealing with acne, eczema, or any kind of sensitivity. And because it’s anti-inflammatory and antimicrobial, it doesn’t just treat problems — it helps prevent them.

Why It Belongs in Your Routine
  • Fights acne-causing bacteria without the harsh side effects
  • Soothes redness, itchiness, and inflammation (especially after workouts, shaving, or sun)
  • Supports wound healing and skin recovery
  • Safe for sensitive areas, even around the eyes or post-procedure
  • Great as a post-cleanse mist or midday skin refresh
How to Use It
This one’s easy. You can mist it directly onto clean skin — morning, night, or anytime your face feels irritated or grimy. Let it dry naturally, then follow with the rest of your skincare. You can also use it on bug bites, razor burn, minor cuts, or even to freshen up your pillowcase. It’s seriously that versatile.

Who Should Use Hypochlorous Acid?
If you’ve ever said your skin is “reactive” or “just won’t calm down,” this is for you. HOCl is a lifesaver for acne-prone, sensitive, or barrier-damaged skin, but honestly, anyone can benefit from it. Whether you’re fighting breakouts, dealing with post-inflammatory redness, or just need a fuss-free skin reset — this is the calm in your skincare storm.


DISCLAIMER: All skin care articles are intended to help educate on specific ingredients and skin care topics. Our articles are written to be informative and informational. Any reference to a specific patient experience is not a medical suggestion for treatment. Please note that any Prequel products with referenced ingredients are formulated for Cosmetic Use Only and NOT intended as replacements for physician advice and/or pharmaceutical product recommendations.

Written by

Honeydew Labs Team

Shop all

Hypochlorous Acid Spray

Hypochlorous Acid Spray

Hypochlorous Acid Spray

$12.95 – $42.75
Forehead and Smile Line Wrinkle Patches

Forehead and Smile Line Wrinkle Patches

Forehead and Smile Line Wrinkle Patches

$19.75 – $26.95
Daily Defense Duo

Daily Defense Duo

Daily Defense Duo

$28.50
Ultimate Cleansing Trio

Ultimate Cleansing Trio

Ultimate Cleansing Trio

$42.75