Hypochlorous acid (HOCl) is a total game-changer—super effective, non-toxic, and safe for all kinds of uses, from cleaning wounds to disinfecting your home. But here’s the deal: just because it’s gentle doesn’t mean you can mix it with anything. Some combos can be straight-up dangerous. Let’s break down what you should NEVER mix with HOCl and why.
1. Bleach (Sodium Hypochlorite)
If you only remember one thing from this list, let it be this—do NOT mix HOCl with bleach. Seriously. Mixing them creates chlorine gas, which is super toxic. Just don’t. Products like Clorox® Regular Bleach or Seventh Generation Disinfecting Bleach should stay far away from HOCl.

2. Ammonia-Based Cleaners
Trying to double up on cleaning power? Bad idea. HOCl mixed with ammonia-based products (like Windex® Original Glass Cleaner or Lysol® Power Bathroom Cleaner) can create chloramine vapors, which are nasty for your lungs and eyes. Definitely not worth it.

3. Hydrogen Peroxide
You might think mixing two disinfectants makes them even stronger, but in this case, nope. HOCl and hydrogen peroxide together can cause a corrosive reaction or, in high concentrations, even explode. Keep it away from products like Neutrogena® Rapid Clear Stubborn Acne Cleanser (which has peroxide) or Clairol BW2 Powder Lightener (a common hair bleach).

4. Vinegar or Acidic Cleaners
Vinegar lovers, listen up! While vinegar is great for cleaning, mixing it with HOCl is a bad move. This combo releases chlorine gas, and inhaling it can seriously mess with your breathing. So, avoid pairing HOCl with products like Heinz® Distilled White Vinegar, Lime-A-Way® Cleaner, or CLR® Calcium, Lime & Rust Remover.

5. Alcohol-Based Cleaners or Sanitizers
Ever heard of chloroform? Yeah, that thing from old-school crime movies. Mixing HOCl with alcohol can actually create chloroform, which is toxic and can make you dizzy, nauseous, or even knock you out in high enough amounts. Not a good time. Keep HOCl away from things like Purell® Advanced Hand Sanitizer or Isopropyl Rubbing Alcohol 70%.

The Bottom Line
Hypochlorous acid is awesome—when you use it right. Just keep it simple and don’t try to mix it with other stuff. It works great on its own, so let it do its thing.
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Do you want to know how you could use hypochlorous acid to treat blepharitis? Check out our blog now!
Disclaimer:
This article is for informational purposes only and should not be taken as professional chemical safety advice. Always read product labels and follow manufacturer guidelines. If you accidentally mix something dangerous, open windows, get some fresh air, and seek medical help if needed.
References:
Centers for Disease Control and Prevention. (2020). Chemical Disinfectants: Guidelines for Safe Use. Retrieved from https://www.cdc.gov
National Institute for Occupational Safety and Health. (2019). Chlorine Gas Exposure and Safety Precautions. Retrieved from https://www.cdc.gov/niosh
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