When used as directed, hypochlorous acid (HOCl) is an easy, everyday “reset” step: a quick mist that can help skin feel fresher and look calmer when you don’t want a complicated routine.
Why HOCl is so versatile
Your immune cells naturally produce HOCl, a molecule that aids in controlling the growth of bacteria and inflammation. It is used in water-based skincare sprays at low concentrations. Both broad antimicrobial activity and anti-inflammatory effects are described in dermatology reviews. According the review, HOCl has a long history of use in wound care settings and, when prepared correctly, has good tolerability.
Everyday ways to use a hypochlorous acid spray
1) After workouts (face + body breakouts)
Sweat and friction can leave skin feeling sticky. A light mist can be a gentle “in-between” step until you can shower.
2) After shaving or hair removal
Shaving can cause tiny micro-irritations. Spritz, let it dry, then moisturize for comfort.
3) Mask friction or long days
If masks, scarves, or helmets leave skin looking flushed, HOCl can refresh without feeling stripping.
4) Eyelid/lash-line hygiene (only if labeled for eyes)
Clinical guidance and studies discuss hypochlorous-acid lid cleansers as part of eyelid hygiene for blepharitis/meibomian gland issues. Don’t spray directly into eyes—follow the label.
How to use it
- Mist onto clean or “mostly clean” skin, air-dry, then moisturize.
- If you use acids/retinoids, apply HOCl first if you want a calmer base.
- Store as directed; stability and packaging matter for HOCl performance (Del Rosso & Bhatia, 2018).
FAQ
Is HOCl the same as bleach? No. Household bleach is typically sodium hypochlorite; HOCl is different chemistry and is also made in the body.
How often can I use it? Many people use it 1–3 times daily. If you sting or feel drier, reduce frequency or stop.
Can it replace cleanser? Not usually—think supportive step, not your main wash.
Disclaimer
This article is for education only and is not medical advice. If you have a skin condition, eye symptoms, or persistent irritation, check with a qualified clinician.
References
- Amescua, G., Akpek, E. K., Farid, M., Garcia-Ferrer, F. J., Lin, A., Rhee, M. K., Varu, D. M., & Musch, D. C. (2019). Blepharitis Preferred Practice Pattern®. Ophthalmology. https://www.aaojournal.org/article/S0161-6420(18)32645-9/fulltext
- Block, M. S., & Rowan, B. G. (2020). Hypochlorous acid: A review. Journal of Oral and Maxillofacial Surgery. https://pmc.ncbi.nlm.nih.gov/articles/PMC7315945/
- Del Rosso, J. Q., & Bhatia, N. (2018). Status report on topical hypochlorous acid: Clinical relevance of specific formulations, potential modes of action, and study outcomes. The Journal of Clinical and Aesthetic Dermatology. https://pmc.ncbi.nlm.nih.gov/articles/PMC6303114/
- Mencucci, R., Favuzza, E., Becatti, M., Cennamo, M., Tosi, G. M., & Selvaraj, R. (2023). Hypochlorous acid hygiene solution in patients affected by blepharitis: A prospective, randomized study. BMJ Open Ophthalmology. https://bmjophth.bmj.com/content/8/1/e001209
If you’re looking for a hypochlorous acid spray, you can learn more about our formulation here. It’s also available through select retailers, including Amazon.
To support your anti-aging goals, you can also find our wrinkle patches on Amazon.
Written by
Honeydew Labs Team
